Glycolysis, Gluconeogenesis, and Glycogen Metabolism

Glycolysis & Gluconeogenesis

Von Gierke disease, is the most common of the glycogen storage diseases. This genetic disease impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis. A deficiency in which of the following enzymes would lead to this disease?

Angel waddles into class one morning complaining of intense bum soreness that she says is from her CrossFit “workout” the previous evening. This soreness is in part due to the accumulation of lactate. Which of the following best explains the reasoning for why there is an accumulation of lactate during heavy intense exercise?

Which of the following enzymes is involved in a reaction unique to gluconeogenesis?

Which enzyme in carbohydrate metabolism works as a tight control point for both the anabolic and catabolic pathways, ensuring that glycolysis and gluconeogenesis are not both active at the same time?

For a combination of reasons, high consumption of alcohol leads to a depletion of which carbohydrate metabolite?

What is TRUE about fructose metabolism?

Which of the following regulators when present will decrease or inhibit the formation of Acetyl CoA from Pyruvate by activating PDC Kinase?

The conversion of Fructose-6-Phosphate to Fructose-1,6-Bisphosphate is a highly regulated part of glycolysis. Which of the following is an agonist of this step?

Which of the following pairs would show a similar Lineweaver-Burke graph?

Which step in glycolysis is unable to proceed if there is a shortage of NAD+?

Which of the following is required to produce additional NADPH in order to fuel Glutathione Reductase to reduce glutathione?

Which of the following is most characteristic of Glycolysis?

A mutation in PFKFB genes 1-4 on chromosome X leads to non-functional PFK-2/FBP-2 enzyme. What effect does this have on metabolism?

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