Blood Cells & Hematopoiesis Published on August 30, 2020 by ehudspeth Blood Cells & Hematopoiesis The picture below shows a: Lymphocyte Eosinophil Monocyte Basophil Neutrophil A CBC reveals depressed levels of monocytes, what would be the most effective course of treatment to boost the number of monocytes? Administration of: IL3 SCF Tpo M-CSF GM-CSF A patient comes into your office complaining of prolonged bleeding after they cut themselves while preparing dinner. You immediately consider that something must be wrong with their ability to clot/coagulate blood. If you are correct, what lab result would you most likely find? Deficiency of Epo Excess Epo Deficiency of Tpo Excess Tpo Excess IL-6 Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds the normal range. Which of the following infections would most likely result in eosinophilia? Malaria Influenza A Dengue Hookworm infection Bacterial meningitis A patient comes into your clinic with defective red bone marrow and hematopoietic stem cells. You realize this condition can lead to Pancytopenia. What do you suspect this patient to have? Aplastic Anemia Polycythemia Sickle-cell Disease Malaria Pernicious Anemia Lab tests reveal that your patient has low levels of the colony-stimulating factor erythropoeitin (Epo). Which CBC result would be consistent with this finding? Lower than normal red blood cells Higher than normal red blood cells Lower than normal T & B lymphocytes Lower than normal granulocytes Red blood cells, lymphocytes and granulocytes would all be lower than normal because Epo is a growth factor common to erythropoeisis, lymphopoeisis, and granulopoeisis A patient comes into your clinic complaining of chronic fatigue. You decide to take a blood sample and see the following image under your microscope. What’s the diagnosis, doc? Bacterial infection Sickle cell anemia Babesiosis Porphyria M-GSH deficiency Which of the following is NOT true regarding the spleen? A splenectomy would leave patients at a higher risk of infection due to low monocyte count Spleen develops during the hepatosplenothymic phase of fetal development during weeks 4-8 Severe blood loss can be mitigated by limited production of RBCs within the spleen The spleen develops from the intermediate mesoderm The spleen is responsible for recycling iron within the body You are on a surgical rotation when a resident asks you to run a CBC on a patient that has had a relatively recent lung transplant. Which of the following would indicate that the patient is at an increased risk for rejection of the donor tissue? Elevated monocyte count Elevated Basophil count Elected Eosinophil count Elevated Neutrophil count Elected Lymphocyte count Samuel presents to your clinic with a runny nose, sore throat, and cough. After running basic blood test you note that his eosinophil count is extremely elevated. What type of infection should be of primary concern? Bacterial Viral Parasitic Fungal Prion While on your pathology rotation you are asked to observe a particular leukocyte that is noted to lack granules. Which of the following cells could you potentially be viewing? Monocyte Neutrophil Eosinophil Basophil Lymphocyte While playing with your new kitten, Dwight, he scratched you out of the blue for no reason, as kittens often do. Your hand starts bleeding. Which of the following parts of the body would you expect to ramp up its thrombopoietin production in response? Stromal cells of bone marrow Endothelial cells of bone marrow Helper-T cells Hepatic cells Macrophages What type of granulocyte is known as the “first responders” concerning infection sites and is expected to dye “neutral pink” when exposed to H&E staining? Monocyte Neutrophil Eosinophil Basophil Lymphocyte A patient comes to your office after being exposed to poison ivy. Which of the following progenitor cells would you expect to be in excess in your patient? Megakaryocyte Erythrocyte Myeloblast Natural killer cell Plasma cell Natalie has megaloblastic anemia due to her vegan lifestyle and lack of red meat over the past five years. Which of the following would you expect her to be elevated due to it not being utilized? Thrombopoetin Erythropoietin Tumor Necrosis factor-alpha FMS-tyrosine kinase-like ligand 3 Transforming growth factor Which of the following is derived from antigen-stimulated b-lymphocytes, primary producers of circulating antibodies and has a clock face nucleus? Plasma cells Fibroblasts Pericytes Mast cells Basophils As an embryo develops it goes through the following phases of fetal hemopoiesis: Hepatosplenothymic Medullolymphatic Pre-hepatic Medullary Which of the following has the phases in the correct chronological order? 4, 3, 2, 1 3, 1, 2, 4 3, 2, 1 ,4 3, 1, 4, 2 4, 1, 2, 3 Time is Up!